Right now, no CRISPR therapies are FDA-approved for cardiovascular disease, but one siRNA therapy (Inclisiran, 50% reduction from injections every 6 months) was approved recently. Several more in clinical trials, including one with the same target as this CRISPR therapy.
Today's most powerful drugs can reduce LDL cholesterol by 85% total, using a combination of statins + PCSK9 inhibitors + ezetimibe: https://www.empirical.health/medications