In KDE you can set different regions for different types of settings (Settings -> Region & Language), so unlike in Gnome you can mix and match locales. E.g., Mine is set to the US for everything except "Time" which is set to Canada because I prefer using YYYY-MM-DD for the date but AM/PM for time.
I once mentioned "the odd-numbered days of the week", meaning Monday, Wednesday, and Friday, to some Catholic friends and was sharply reminded that the week begins on Sunday.