- there's a small-ish window in the disease progression where pulsed vibration is able to help a person regain some intentional motor control
- the device doesn't stop the tremors
- the pulsed vibration does let the brain's control signal come through stronger, so drawing/typing/moving the mouse is more intentional.
- this is no more effective than the results of levidopa/carbidopa treatment, and the levidopa/carbidopa typically calms the overall tremors
- as Parkinson's progresses, these devices become useless, and if the patient qualifies for deep brain stimulation, it's worth looking into (regain years of useful life if you're lucky).
You can make a very unsophisticated version of this without a lot of hardware:
- small microcontroller with 3v outputs (XIAO's are perfect)
- 3v sealed eccentric mass motors (aliexpress $1/ea)
- elastic wristband
- usb battery
- software to pulse the motors for about 200 miliseconds for an on off sequence of about 8 times, then rest for about a second and repeat.
Side note: the idea was published in 2016-2017 in a few promotional videos from Microsoft research: https://www.windowscentral.com/microsofts-emma-watch-and-pro...
I'm going to look into this when I can. would love to try it if it's financially feasible.
ETA: Looking at their website and all the models in the photos are older people...
As someone diagnosed with ET since high school that's kind of funny.
It comes down to two mismatches: first being the famous person's own patience, which is just a normal amount, but instead of usual number of others going up to them now it's 100 or 1000x the number of others.
The second mismatch is the information asymmetry: the famous person him/herself knows that they have gotten 100x people going up to them and saying / asking the same thing, and they know that they will continue getting this for the rest of their life, so they respond with annoyance, which is completely understandable. However, the average person going up to them isn't gonna think that many logical steps and realize this; they're just saying "oh cool, it's a celeb, I never see celebs. Let me try to talk to them!"
No, I did not try "this one weird trick that doctors hate" and I'm not going to. I'm going to do my own research, I'm going to speak with medical professionals and specialists who understand the MOA of the treatments they're discussing (and what "MOA" even means) because I'm an adult, thanks.
To anyone saying it's not rude: It is when it's just "have you tried X?" because, who the fuck are you? Are you a doctor specializing in my disease? Are you also a sufferer of my disease? Are you a caregiver for someone with my disease? No? Then go away "dude who read something one time".
You want to wander in with unsolicited medical advice, you need to show me that you're not just the same losers I've dealt with my whole life saying "oh man, I have a migraine" when they mean an extremely bad stress headache. I assume everyone with chronic illness has had the same well-meaning gibberish.
It's great that you want to connect with me, but weird that you want to do it about my disease. It might even be a good discussion. But it never is if the lead is "have you thought of this?"
That’s a bit hostile. I happen to have been following research around beta-carbolines for almost two decades and am curious whether clinical practice follows that research. My replies may be curt simply because I am writing on a mobile device.
It is interesting that you should decide to die on that hill, when the parent poster clearly did not have an issue with my question. It was neither directed at you, nor did it concern your disease.
Are you certain of your own motivations?
Are there any studies with results showing this as a suitable way to reduce tremors?
See e.g. https://link.springer.com/article/10.1007/s12311-015-0751-z
My grandfather on the other end of the spectrum and who also had it didn't do those things either.
A (very) quick look at this says that the compounds are doing the damage, but the real problem is that some people don't metabolize them as quickly as others, and they build up. These are neurotoxic at higher concentrations and cross the blood-brain barrier, so if you aren't clearing them out then I guess you're exposing your cerebellum to more of them for a longer duration.
Studies suggest that people with ET have higher levels of these beta-carbolines in their blood than control patients, in some cases (like familial tremor) even if their diet and lifestyle doesn't look it should be risk.
ah, "Today, Encora is focused on building a national sales force and working to secure coverage from insurers."
not that they tested or approved it
it's an often marketed phrase that's meaningless
Ok, maybe you're not reviewing the entire article, but at least the subtitle.
The first digit is the school that offers it, then after the decimal point they have their number of classes. (EECS is unusual in that it has four digits after the decimal point, most every other course has just three.) In general, classes that are required start with 001 and increment up, such that 001 is the intro course, 002 follows from that, etc. Then electives start around 015 or so.
Course 1 is Civil Engineering, Course 2 is Mechanical engineering, Course 3 is materials science, etc. 6 is Electrical and Computer engineering.
So 2.009 is a mechanical engineering course, in this case one for students towards the end of their time. It's called Product Engineering Processes, where you create a new product from beginning to production.
So 6.0002 is pronounced "six triple oh two"?