GRAS is “Generally Recognized As Safe”: so for example you don’t need to do a study on its safety when using it in a drug formulation.
I actually saw the plumber dig up the mains that ran to my place and it was pex.
The only way to replace plastic is work hard on making different materials that beat it in every way and scale them up with massive state investment. Then you're fighting multinational companies, neoliberal economists, anti tech green activists, skeptical scientists and corrupt politicians all at the same time.
*economically/practically, not absolutely
We have some alternatives that work, and some scenarios where we still need to use it, but we can reduce the use significantly. Like Oil and Gas we absolutely do know better in many scenarios and just choose not to.