Alzheimer's trial to test drug on people without symptoms to test prevention(www.theguardian.com)
11 pointsby borski5 hours ago2 comments
  • orangecat5 hours ago
    Good. If https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h... is correct, the reason existing anti-amyloid drugs don't work well is amyloid leads to tau which leads to neurodegeneration, so by the time somebody is impaired by Alzheimer's they already have too much tau and reducing amyloid won't help much.
  • caycep2 hours ago
    My irritation is that it's not till 7th paragraph until they tell us what the drug is.

    It's almost like that's not the important thing.

    Kinda like how political hit jobs just mentions "emails were hacked"; whether the emails had nuclear codes or the target's dry cleaning receipts is not important...

    • genxy34 minutes ago
      And yet you don't tell us either...

      Trontinemab

      > About 1600 healthy adults aged 55-80 who have no symptoms of Alzheimer’s disease or memory problems will be recruited at research sites around the world. Surrey and Borders Partnership is the lead recruitment site in the UK and can recruit participants from anywhere in the country.

      > Trontinemab works by removing amyloid plaques that build up in the brain and are associated with Alzheimer’s disease. Blood tests will be used as part of the screening process to identify people who are most likely to benefit from participating in the trial.

      https://www.sabp.nhs.uk/news/surrey-and-borders-leads-europe...

    • ButlerianJihad20 minutes ago
      > nuclear codes or the target's dry cleaning receipts

      Now that is just ridiculous! Dry cleaners don't email receipts!