It is quite pleasant to work with, because you don't have to worry about a constant stream of vulnerabilities or supply chain attacks. You just vendornthe script in your repo, add it as a <script> tag on the page, and you're done.
For areas that need server side, if you use say react and return a JSON you have to deserialize and do the render. It might be much more efficient to just replace.
Having said that I use HTMX /alpinejs for small projects, and still trust react for bigger more interactive ones.
cheers