For a single database, bigints are smaller and faster, with less footguns.
UUIDs can be nice for an opaque public ID, however I'd still prefer something like a Sqid for space and usability.
But be careful!! Javascript WILL interpret your bigints as Number() and round them down because they are too big without telling you!!!
Famously seen by every snowflake user that has interacted with Javascript, quite an annoying problem.
Inappropriate aliasing of integer keys allows for silent errors in queries because it will actually return some result a lot of the time. A UUID is immune to this problem. The model recognizes its mistake a lot more reliably when previously non-empty tables start showing up empty after attempting a join.
How much trouble does SQLite reysing rowid's actually cause?