why? Web Serial is one of the better web-based integrations out there. There is no functionality available without an explicit authorization, all that website can do is to pop up a dialog. And you approve individual port on per-site basis, so it's not like it can grab a random port without your knowledge.

This is my favorite model for web: anything more complex should be gated behind user permission. A site which requires that functionality will get that permission with no problem, and a random clickbait fingerprinter will get nothing.