I wonder about the editorial choice to use veterans rather than, say, women who have PTSD from assaults, which is a much larger group of people. (Approximately 4% of US men and 8% of US women experience PTSD every year across all reasons like accidents, sexual assaults, combat, etc.)
Presumably this treatment would help everyone? Or is it somehow supporting only vets?
The US also spends a large amount of money on each veteran. If they can find a cure for trauma they would benefit hugely from it. The side effect of this is that others would benefit as well.
J. was a traveling Ibogaine ... healer? He went from city to city, summoned by the loved ones of advanced heroin addicts, to attempt one last Hail Mary shot at recovery.
These were situations of absolute desperation, and I can’t overstate the seriousness with which he took his adopted occupation. He described to us in detail his process.
First, he interviewed the person requesting help, seeing what else they had tried and trying to suss out if Ibogaine would be worth the risk. He turned away most callers.
Those who he accepted would be dropped off at his van, inside which was a mobile, DIY ICU of sorts: a bed, food, water and emergency medical supplies. He would administer the ibogaine (I don’t know what form this took), and then, in his words, the patient would undergo a 2 to 3-day continuous hallucination.
During this time, in J.’s observations, the patient was almost always ‘visited’ by dead relatives, who typically admonished the patient for what had become of them, laying into them with real talk about the state of their life.
J. said half of the patients came out of this experience fundamentally changed, and effectively cured of their addiction to heroin. I don’t know if he had any data (anecdotal or otherwise) on recidivism, but the implication was that this was likely to be permanent.
But, he said, the other half went insane, which is why he spent a great deal of effort screening families and informing them of the risks.
I don’t know how much, if any, of this is true. I don’t know what ‘insane’ means, or meant. But I remember vividly how seriously this guy took it, without ever coming off as some kind of self-satisfied guru or medicine man, believing himself to be a god, or anything like that. He never accepted money. He lived somewhat roughly. I wonder whatever happened to that guy.
We’re one step below “think of the children”
from https://pubmed.ncbi.nlm.nih.gov/41883580/:
>Longitudinal analyses assessed cortical thickness, subcortical volume, and predicted brain age (pBA), estimated from T1 scans. pBA was significantly reduced at 1 month relative to baseline (-1.3 years). Cortical thickness analysis revealed post-treatment increases in 11 regions. Subcortical analyses revealed significant volumetric expansion in 8 regions. Magnesium-ibogaine therapy was associated with increased cortical thickness, subcortical expansion, and reduced pBA at 1 month.
PTSD is a trauma response.
Are you thinking of TBI? TBI is a cumulative impact of small and large head trauma.
Lot of interesting studies and anecdotes on its efficacy as an antidepressant
https://en.wikipedia.org/wiki/Ibogaine
"The action of ibogaine at the κ-opioid receptor may indeed contribute significantly to the psychoactive effects attributed to ibogaine ingestion; Salvia divinorum, another plant recognized for its strong hallucinogenic properties contains the chemical salvinorin A, which is a highly selective κ-opioid agonist"
However there is certainly a lack of data, and facilities doing treatment now are probably incentivized not to share adverse events.
If dissociation is better than regular PTSD, then go for it. We don’t expect people with hip replacements to have 100% mobility. We don’t expect cochlear implants to hear better than healthy ears. Mental health interventions have similar tradeoffs.
The healthcare community would be thrilled to find out – with certainty – that your interventions work.