Individuals with irregular bedtimes had a 2.01-fold higher risk of MACEs compared to those with regular bedtimes (HR = 2.01, 95% CI: 1.00–4.01, p = 0.049), and those with irregular sleep midpoints had a 2.00-fold higher risk compared to those with regular midpoints (HR = 2.00, 95% CI: 1.01–3.98, p = 0.048).

So it doubles one's chance of a heart attack or stroke. Gnarly.

I wonder what "irregularity" means. It seems they didn't define this clearly. Are we talking about few hours or is this a weekly night shift flip flop.