Your cold-outreach emails will be flagged as spam by some people, even if they comply with CAN-SPAM. And you should comply with it by having a clear opt-out mechanism and your physical address in the footer, but some people will flag your emails regardless.
I've had this happen in my startup. It hurt the deliverability of our transactional emails (notifications etc.). I'd go with a separate domain if I had to do it over.