> We gave pregnant rats drinking water with BPA levels similar to those considered safe for humans in 2015. We observed lasting effects in their offspring exposed to low-dose BPA. BPA caused notable female masculinization and male feminization. These sex-specific effects resembled those seen in people with metabolic syndrome, a set of health problems that raise the risk of diabetes and heart disease. Our results imply that reducing BPA use in food and beverage containers could help prevent these outcomes.