I don't do side projects with a goal of commercializing them. They're hobbies.
For research, pick an existing project and make it efficient.
For building a startup, pick one that solves a problem for many people and makes money.
The last one doesn't come without problems and now has just gotten even harder. It used to be 90% of startups failing.
Now it most likely is going to be 98% of startups failing.