Supplementation with vitamin D3 reduced telomere attrition(www.sciencedirect.com)
36 pointsby felineflocka day ago4 comments
  • a day ago
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  • robwwilliams19 hours ago
    There is at best modest support that shortened leucocyte telomeres cause differences in lifespan. Results of Mendelian randomization studies are weak and causality is uncertain. Some evidence that longer telomeres may increase cancer risk.
  • globular-toasta day ago
    So you can supplement 2000IU year round without getting calcium build up? My problem with vitamin D is it's really not clear how much is safe to supplement.
    • dharma1a day ago
      Always take d3 with k2
  • maipena day ago
    Pretty good news! But also I think this study tells us that people are infact staying in doors more then they should! Our levels of vitamin D are likely really low in general otherwise we wouldn't see that much of a diference.

    I bet the supplement industry is going to be splashing this study all over the internet for the next few months.

    • kelseyfroga day ago
      I go to the dermatologist and get told to avoid the sun. I follow their advice and then go to my GP. He said vit-D is low so I supplement.

      It feels like a failure of communication, but who knows. I only see one Dr at a time.

      • TylerLivesa day ago
        I don't see how being in the sun could be bad for us. We've been doing it for as long as we've existed and every other form of life does it as well. Anecdotally, I feel amazing when I'm sunbathing and I feel terrible during winter when there's less sun. The only explanation I can come up with is that modern people are somehow uniquely sick so their bodies can't do what every other organism has done for billions of years.
        • kelseyfroga day ago
          The American Cancer Society seems to advise differently:

          There are no safe UV rays[1].

          Exposure-incidence models agree[2].

          1. https://www.cancer.org/cancer/risk-prevention/sun-and-uv/sun...

          2. https://pubmed.ncbi.nlm.nih.gov/25213656/

          • ravenstinea day ago
            That's been my conclusion recently. While I'm sure it's true that people aren't getting enough vitamin D because they are indoors a lot, I'm not convinced you can't easily get enough of it in supplement form. If UV is only needed for vitamin D then you might as well avoid the aging effects of UV exposure and pop a pill.
            • amanaplanacanala day ago
              I don't think we know the entirety of what happens in the skin with UV exposure. We are pretty sure that vitamin D is good, and that cancer is bad, and that seems to be all that people talk about, but there are a lot more things happening that we don't fully understand.

              I suspect when we know more, the best answer is going to be moderation. But it's really anybody's guess right now.

              • kelseyfroga day ago
                There are even things that we do know about but generally aren't talked about such as UV-triggered nitric oxide release[1] which moderates blood pressure among other positive effects.

                I want to be clear that there being pros and cons whose relative proportions change is very different than what some other commenters seem to be implying which is closer to a threshold model of UV safety which clearly doesn't exist and is non-scientific.

                1. https://www.nature.com/articles/s41598-022-13399-4

          • on_the_traina day ago
            Uv rays are not safe. But not getting uv rays is also not safe. Like so many things in biology, bodies are optimized for ranges in the middle and not at the extremes.
        • helph67a day ago
          I'm aware of the importance of wearing a hat (with a brim) when in sunlight, to protect scalp and ears from UV radiation. "Researchers think the three primary types of skin cancer -- melanoma, basal cell carcinoma, and squamous cell carcinoma -- are mostly caused by too much time in the sun. So it’s very important to use sunscreen or cover up if you’re going to be outside longer than 15 minutes or so." https://www.webmd.com/a-to-z-guides/ss/slideshow-sunlight-he...
        • didntknowyou21 hours ago
          there's nothing wrong with being in the sun. but there's no denying UV rays damage the skin, accelerating the signs of ageing- hence the recommendation by dermaotlogist to avoid it.
      • juliangmpa day ago
        I think there's quite large gap between vitamin D deficiency cause you don't get any sunlight and getting so much sunlight that it's unhealthy.
        • perrygeoa day ago
          As with anything health/nutrition related, the debate gets so comically two-sided with reductionist arguments talking past each other.

          Get some sunlight but don't get a sunburn. It's not rocket science.

          • kelseyfroga day ago
            I'm not sure how you square that with findings that show any increase in UV exposure is associated with all-cause mortality[1]. It would seem that in this case common sense is bad sense.

            1. https://pmc.ncbi.nlm.nih.gov/articles/PMC3736750/

            • perrygeo21 hours ago
              This is exactly what I mean. You cite a single 12-yr old study and extrapolate its conclusion to extremes.

              No mention of the Swedish cohort study (Lindqvist 2016) showing sun-avoiders had 2x mortality risk over 20 years. No mention of the dozens of ecological studies showing inverse relationships between UV and many cancers.

              I could go on all day. You can't just paste one link and call it settled science.

              • kelseyfrog20 hours ago
                For your consideration a 2025 meta-analysis[1] of 73 eligible articles concludes no change to current avoidance recommendations.

                You'll notice that Lindqvist 2014, 2016, and 2020 are references 77, 78, and 79 respectively. Definitely interested in what evidence would change your mind. Any chance you could describe your evidentiary bar?

                1. https://pubmed.ncbi.nlm.nih.gov/41415029/

    • smt88a day ago
      I'm outside a lot, but I'm in a less sunny climate than my ancestors and have a vitamin D deficiency all year round