There are advantages and disadvantages to remote and in-person work. For a startup, I think the advantages, specifically access to a larger (and likely cheaper) talent pool better fits the needs of a startup. A disadvantage is less team alignment, which can be compensated for with good management practices.

Remote. Using tools like virtual frosted glass (https://meetingglass.com/), you can mitigate the downsides of remote work, such as loneliness and isolation.