Psilocybin triggers activity-dependent rewiring of large-scale cortical networks(www.cell.com)
48 pointsby QueensGambit16 hours ago5 comments
  • drooby14 hours ago
    Obsessive Compulsive Personality disorder (OCPD) is actually way more common than people realize, but it barely gets talked about compared to other mental health issues - and it may even be more of a root cause of things like anxiety, depression. and it is often confused with autism.

    What’s interesting about this research is that it points to a possible biological reason why something like psilocybin might help, I.e it seems to loosen really rigid brain patterns. That’s basically the core issue in OCPD: being stuck in overcontrol and perfectionism. It’s not a treatment yet, but it does help explain why psychedelics could be useful for this kind of rigidity.

    Would love to see more talk about this - OCPD is often overlooked both by the general public and unfortunately by those impacted by it

  • N_Lens7 hours ago
    Mice are going to have the best mental health in the Universe before the decade is out.
  • khelavastr9 hours ago
    So do 5hT2a receptors when stimulated by DMT-family compounds from INMT during dreamy sleep.
  • renewiltord5 hours ago
    Drugs people want to legalize found to be therapeutically indispensable. Law that specifically allows only these categories found to be unrelated to this mechanism.
  • NotGMan4 hours ago
    Many mental illness are now being fully resolved after ~9 to 12 months on a low carb diet.

    Not a magic bullet (since I know many idiots will comment who are incapable in thinking in probabilities but only think in black and white), but the fact that some people were fully healed or at least partially improved their life quality is obviously insane progress compared to any medication, which either doesn't work fully or stops working over time.

    This channel has more examples: https://www.youtube.com/watch?v=Mlku8oWrQLk

    • KempyKolibri4 hours ago
      We have some case studies and pilot studies without any kind of control. Perhaps keto/low carb could be helpful (it certainly is with epilepsy!), but I certainly haven’t seen any evidence that it’s superior to other diets that achieve the same things (I.e. weight loss, or higher clinician contact time - a lot of these pilot studies end up losing a bunch of weight and getting several extra hours per week of contact with their clinician - who knows if much/all of the benefit comes from this?).

      Having had quite a lot of experience with the keto/low carb crowd, I think we’d see a lot more adoption/interest in their ideas if they approached things in a less ideological/dogmatic way. It’s hard for responsible clinicians to get involved with, say, Metabolic Mind when people like Bret Scher hand wave around the CVD risks from high SFA intakes, or big up low quality work like the godawful Keto-CTA paper.

      There _are_ responsible keto advocates out there like Ethan Weiss, and I suspect that if the keto/low carb community were to promote _their_ work rather than that of people like Nick Norwitz and Dave Feldman then their diet of choice would be taken more seriously.

      Unfortunately much of the low carb movement is quack town at the moment. I hope they get their act together, there are benefits in there for people in need, but they need to get serious first.