130 pointsby rmason17 hours ago13 comments
  • throw484728513 hours ago
    Popular Mechanics is like Popular Science right? Extremely bullish on new technologies to the degree of taking one study and turning it into a breathless article about how we're 1 year away from flying cars?

    Sorry for the cynicism, but I grew up subscribing to Popular Science and I gained a very jaundiced view of this kind of science/technology popularizing

  • galkk11 hours ago
    Unrelated to the growth topic, but related to teeth.

    5 or something years ago I read here, on hn, about novamin/biomin and started to buy toothpaste with it.

    Since that I had 0 cavities, even if my toothcare routine isn’t the best: most of the time I brush only in evening and when I had severe clinical depression episode I could go weeks without brushing.

    • card_zero10 minutes ago
      OK, and my anecdote is that for forty years I used no toothpaste at all, brushed only before bed, didn't floss, never went to the dentist, and had perfect teeth. The conclusion of this limited study is: whatever.

      I guess I should admit that eventually I got lazy and skipped a night, and immediately got a cavity that led to having a tooth removed, and now I use toothpaste and floss. But still, anecdotes, what are they worth.

    • steve_adams_864 hours ago
      Sort of tangential: I used to be able to tell episodes of depression were setting in because I'd stop brushing my teeth. It was the clearest indicator I can recall.

      I'd then brush my teeth hoping it would cure the depression. It clearly worked, because I'm no longer depressed. It just took a few years to kick in.

      Always remember to brush your teeth.

    • animal531an hour ago
      You can do the same by just kissing a person with the right mouth biome.
    • edgineer9 hours ago
      Counter-anecdote, I did the same, got Burt's Bees with novamin when they still sold it (discontinued), then switched back to Crest. I prefer the Crest. No cavities either way, but tooth sensitivity and clean feeling differences. A tooth chip I wondered might remineralize, i.e. grow back or fill in or something, had no change.

      My guess is the SLS detergent, present in Crest and not in Burt's, is the more significant factor.

      • galkk8 hours ago
        I always had sensitive teeth (and brush exclusively with sensodyn for many years) so I guess this is less of a factor for me.

        I buy Canadian? Sensodyne that has novamin in it.

    • CrimsonRain6 hours ago
      Any idea about mHAP (hydroxi apatite)
    • wakawaka2810 hours ago
      Do you eat much sugar? Soda or juice? These things make a huge difference. So does age. Young people get cavities easier than somewhat older people.
      • anonzzzies8 hours ago
        Is there also not a some genetic aspect there? It is a question as I do not know but always assumed as I always did whatever and have 0 cavities or anything else that other people seem to have and I am almost 60. Never have receding gums, sensitivity, cavities or anything else since I was born.
        • wakawaka288 hours ago
          There is a genetic aspect I'm sure. But I think most people don't avoid consequences of, say, drinking lots of soda while not brushing teeth. I bet there are nutritional factors too. If you are chronically malnourished, your teeth may be worse somehow.

          I think regularly brushing your teeth and getting cleanings makes a big difference obviously. Gum disease or gingivitis mainly happens to people who have long-term dental care issues or certain bad habits.

      • galkk7 hours ago
        I drink sugar free sodas all my life.
  • Fraterkes15 hours ago
    Confused a bit by the article: it mentions human trials began in september 2024, but also that the trials that might prove it working are yet to start?
    • magicalhippo15 hours ago
      I think it's just poorly written. If you go to the source[1] the trial period was planned from September 2024 to August 2025, and the submission says people are "undergoing" a trial. Perhaps it got delayed, or, more likely IMHO, the trial period is over and they're studying the data so haven't made reached a conclusion yet.

      [1]: https://www.kitano-hp.or.jp/info/20240503

    • MajesticHobo214 hours ago
      It’s a phase 1 clinical trial designed only to assess safety and determine the appropriate dosage. Future trials will focus on efficacy.
  • ezoe3 hours ago
    I've been hearing this for as long as I can remember and I'm not young anymore.
  • abootstrapper12 hours ago
    I’ve heard this for the last 20 years.
  • TylerE14 hours ago
    This is like fusion energy. It's been 4 years away since I've been a child.
    • amelius14 hours ago
      I personally regrew my teeth since I was a child. Granted, once.
      • gambiting14 hours ago
        Fun fact - all of your adult teeth were already there from the start, hiding under(inside?) the gums. We don't "grow" new teeth when the baby teeth fall out - the adult teeth were always there under them.
        • rokob11 hours ago
          This is not true. I’ve seen x-rays of a child’s mouth with clearly no adult teeth visible below the gums. Later I’ve seen X-rays of the same mouth with one or two adult teeth below the gums where baby teeth are about to fall out. The adult teeth are there underneath once the baby teeth fall out but they are not there “from the start”. That isn’t even to mention the size problem.
        • compsciphd4 hours ago
          so I used to think this (till this past week), it's not quite true. Yes, ther are images of showing child skulls with lots of teeth. those are generally hyperdontia.

          A regular child skill looks more like this x-ray

          https://ccdcsmiles.com/userfiles/651/images/IMG_4253.jpg (from a dental clinic I found while searching).

          Yes, you can see the adult teeth, but not all of them, and not like the hyperdontia cases.

        • dekhn13 hours ago
          Did they get bigger as you were "Growing up"? Then we grow teeth, you're just being pedantic about whether they're brand new or not.
          • Dylan1680712 hours ago
            It's not pedantic in this context unless you already have a way to set up fresh seed teeth.
        • tstrimple11 hours ago
          It may be fun, but it's not a fact. At birth, you likely have all the tooth buds to grow your primary teeth and maybe your permanent molars. Premolar and canine buds typically form during the first year of life. Second molar buds form around age two. Third molar (wisdom teeth) buds don't begin developing until around age five to six and in some folks they don't grow at all.

          I have a condition where my lower front permanent teeth never developed. We weren't sure if any of our kids would have the same issue so we discussed it with the dentist. They couldn't tell us if all the permanent teeth were present or developing because there hadn't been enough time for first xrays to show all of the permanent teeth buds growing. Even at age 3.

  • bumblehean15 hours ago
    Aren't the shape/size/placement/etc. of human teeth fairly unique across different individuals? At least unique enough to use dental records to identify bodies.

    I don't see if mentioned in TFA, but if new human teeth can be grown is it expected that the new ones will just grow in "correctly" to fit a person's mouth?

    • throwup23814 hours ago
      > At least unique enough to use dental records to identify bodies.

      Yes but in comparative dental analysis they use ante-mortem dental records to compare with post-mortem remains. It's not like DNA where you can record it once and then use that to match samples decades later in a database. In order to have a high confidence in a match, recent x-rays and records of dental work like fillings, crowns, etc. work best.

      And no it is not expected. It's one of the primary challenges with bringing these kinds of drugs to market, as hyperdontia is already relatively common among humans (I had an incisor growing at the roof of my mouth an inch behind my row of teeth). Most successful applications of these tooth regrowth drugs tend to place them near the root of missing teeth hoping that the cellular growth signaling mechanisms are still working.

    • clickety_clack15 hours ago
      Teeth wear quite a bit too, I wonder will new ones have to be pared down to fit.
  • valunord11 hours ago
    Old news. They were doing this with ultrasound successfully 20 years ago. I know a guy who a tooth back with his own device.
  • piskov14 hours ago
    Let’s hope teeth won’t grow in places they shouldn’t.
  • RomanPushkin13 hours ago
    Don't need teeth yet (lol), but curious if anyone is aware of a similar/new ways to restore the enamel?
  • msuniverse202615 hours ago
    Scientists regrowing everything except hair. Fuck my life.
    • cebert13 hours ago
      I am hoping for advancements in cartilage growth. I underwent microfracture surgery in my knee and will eventually need a replacement unless we make progress in this field. I would prefer to avoid knee replacement if possible because I enjoy being active. I am hopeful we’re getting close.
      • tmtvl2 hours ago
        In the summer my knees were so wrecked I could barely make it up and down the stairs. My GP first thought it was an inflammation and prescribed something for that, but when I went back after a couple of weeks he said the cartilage may have worn off and prescribed me Flexofytol. It may be placebo effect, but between taking it a bit easier, cycling more, and the flexofytol, my knees are the best they've been since I injured them in the first place.
      • esseph13 hours ago
        Anecdotal, but I was going in for carpal tunnel work and ran into an older gentleman, probably early 70s, that had just gone through a knee replacement a week earlier. He was walking around on it and said he wasn't really in any pain.

        I was amazed.

        YMMV.

        • cebert12 hours ago
          I have heard great things about knee replacements. Unfortunately, I’m relatively young (late 30s). If I were to get a replacement now, I’d likely need another one when I’m older. Additionally, I imagine getting an artificial knee replacement would make you no longer a candidate for lab-grown replacements. There is an option already where they can grow your cartilage in a lab, but it’s quite expensive, and my insurance will not cover it.
    • derektank12 hours ago
      Phase 2 trials on PP405 just completed. They’ll probably begin phase 3 trials sometime next year if you’re looking to enroll.

      https://clinicaltrials.gov/study/NCT06393452

    • kolinko6 hours ago
      $4k and a trip to Turkey. I did it last tear and can recommend :)
    • gensym8 hours ago
      My meniscus would like a word.
    • xenospn14 hours ago
      And limbs.
      • piskov14 hours ago
        I would say every tissue: no bones, no organs, eyes, ears, nerves, skin.

        Like what can they grow?

        • kylecazar13 hours ago
          Well, I'm personally hoping stem cells pull through for corneal tissue regrowth. I've got significant scarring in one eye. I'd rather not get a donor (cadaver) cornea sewn on if it's avoidable but we'll see.

          I think they're making progress.

        • janice199913 hours ago
          The liver is an exception here - you can grow back a lot of it.
          • piskov3 hours ago
            Not many times tho: see cirrhosis
        • drdeca11 hours ago
          Eh? They can grow skin cultures that are good enough to help burn victims. Not, like, with all the pores and follicles being there, but it is skin…
    • zaken14 hours ago
      finasteride + minoxidil
      • janice199913 hours ago
        Just keep your mental health in mind - there's growing concern that the link between finasteride and depression has been underestimated [0].

        [0] https://www.psychiatrist.com/jcp/analytical-review-depressio...

      • b3ing10 hours ago
        Finasteride can make you have man-boobs, it’s a known side effect
      • piskov14 hours ago
        Once the follicle is closed/gone, it’s gone.

        Minoxidil won’t help grow hair on a patch of bold skin. After that only hair transplantation

        • socalgal214 hours ago
          I'm sure you're correct. That said, I saw a friend who went bald at 28 get all of his hair back from Minoxidil + finasteride. Maybe his folicles weren't closed/gone but he was bald and a year later, was not.

          Apparently there's also now-a-days, Micro-needling, Stem Cell Therapy, Platelet-Rich Plasma, and others. No idea how effective they actually are

          • hsuduebc214 hours ago
            Well he even had alopecia or he got hair transplant. There is sadly no other option.
            • dpark10 hours ago
              What does that mean? Alopecia is the general term for hair loss.
              • hsuduebc29 hours ago
                Sorry my bad. It's called that way in where I'm from. The hair loss is mostly due to mechanism similar to pattern baldness but the hair loss can occur even without death of hair follicles. It could also be triggered by some autoimmune disease.
        • dpark11 hours ago
          This isn’t the whole story. Many people have follicles that are dormant. Many people have success regrowing hair on bald spots with minoxidil and/or finasteride.

          If you look like Sir Patrick Stewart, yeah, that’s not growing back. A bald spot might fill in with medical treatment though.

      • simmerup14 hours ago
        If you don't have sides that is
  • m3kw915 hours ago
    Growth rate and how you don’t mess it up before it matures are problems
  • zingababba15 hours ago
    I've been taking vitamin k2 mk4 at 45mg a day for over a year now. My teeth feel gr8. Now I need to get some of this stuff to have super human chompers.
    • epicureanideal15 hours ago
      What changes in your subjective sensation of your teeth with K2?
    • giardini13 hours ago
      This guy's been downvoted badly but he's right - vitamin k2 make your teeth into "superteeth".

      I started K2 about 10 years ago. Next dental checkup (about a year too late) the dental tech said my teeth appeared recently-cleaned. This has continued since then. No cavities, little cleaning required other than regular brushing, flossing and taking k2.

      • resoluteteeth10 hours ago
        IIRC plaque is mineralized by saliva in the same way as tooth enamel, so something that changes saliva in a way that prevents tartar from forming might be reducing the amount of calcium in your saliva in a way that could potentially ultimately not be good for your teeth.
    • terribleperson13 hours ago
      Why mk4 over mk7?