Reading articles like these makes me realise how little we know. We barely know anything about the universe, it's huge, incomprehensible, and uncaring.
And what's worse is that our knowledge is not going to change much in my lifetime.
I think we know quite a bit. Maxwell's equations have unified electromagnetism. We actively exploit nuclear for energy (and deterrence of war, but I won't go there) and armchair me thinks there shouldn't be a lot more to the strong and weak forces (~80% of it known?).
What we don't have a good grip on is gravity and time at the ends of big and small (plank and galaxy) scales. And dark matter remains a giant mystery.
Lovecraft’s fiction is among the most accurate as far as the grand scale, I think. At least metaphorically, and for truth-in-the-experience and not truth in terms of physics or whatever.