Drinking alcohol reduces the body's natural GLP-1 activity by 34%(recursiveadaptation.com)
22 pointsby comova5 hours ago5 comments
  • pedalpete3 hours ago
    I was expecting to see this study as related to GLP-1 activity post a night of drinking, and therefore we'd understand the mechanism, as decreased sleep delays GLP-1 activity by 90 minutes (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697408/)

    I'd be keen to understand the pathway by which alcohol intake directly reduces GLP-1 activity.

  • an hour ago
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  • comova4 hours ago
    And if you haven't asked a friend who's on one, taking a GLP-1 medication reduces drinking by about 50%:

    https://recursiveadaptation.com/p/first-ever-randomized-tria...

    • someonehere42 minutes ago
      Can confirm I can’t drink as much anymore and have switched to Lite beers because I don’t feel weird after drinking.
    • an hour ago
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  • tiffanyh3 hours ago
    Which is interesting because there’s a lot of Mediterranean cultures that drink after every meal (lunch & dinner).

    And the reason is “for digestion”.

    So this would suggest the opposite effect is happening. Drinking actually hurts digestion.

    • debugnik2 hours ago
      > And the reason is “for digestion”.

      This is an excuse a few use to justify drinking wine when they know it's "otherwise" unhealthy, but most people here who drink do so simply because they like it.

      • mewpmewp22 hours ago
        I like drinking, but of course this means I also like coming up with weird excuses for why to drink.
    • ipaddran hour ago
      Fermenting grapes is different than any alcohol.
      • resoluteteeth31 minutes ago
        Is it? There has been a lot of research on stuff like antioxidants in wine but as far as I can tell that's largely because of older observational health studies on purporting to show a positive effect from moderate wine consumption which has disappeared in more recent studies that did a better job controlling for confounding factors (like many people who don't drink at all being former alcoholics or having other health issues) which have shown that any alcohol consumption is harmful.
      • tiffanyhan hour ago
        I wasn’t thinking wine.

        More like Ouzo in Greece.

        https://en.wikipedia.org/wiki/Ouzo#:~:text=Ouzo%2520(Greek%2....

  • comova5 hours ago
    "These findings provide compelling evidence that acute alcohol consumption decreases GLP-1, a satiation signal, elucidating alcohol's 'apéritif' effect." This could increase hunger and cravings (including for more alcohol).
    • AtlasBarfed3 hours ago
      The double whammy is that alcohol is an extremely calorically dense substance.

      Even worse, it is consumed in liquid form, which also bypasses some satiation mechanisms in the body.

      There's a reason tour de France riders get most of their replacement calories in liquid form

      • tredre33 hours ago
        Indeed the average base spirit has 2-3 calorie per millilitre. This is 5-6x the amount found in coca cola or pepsi. But then again, the quantities are also much less than when drinking soft drinks (hopefully).
        • squidgedcricketan hour ago
          Glucose and ethanol are metabolized through different pathways that will have different efficiencies. How much impact does that have on comparing the two?

          Glucose can go right into the bloodstream (?), but ethanol needs to be reacted (taking energy) to turn into blood glucose.

          This is a confusion I have about calories-in-calories-out in general, fat/carbs/protein are all metabolized with different (and variable) efficiencies. Even pro-CICO folks agree not to count ingested calories that can't be metabolized, but that's just one spot on a gradient to draw a line.

        • dzhiurgisan hour ago
          IDK I can down a sixpack or two pretty easily. I can’t imagine drinking so much soda or even water.
          • tguvotan hour ago
            you can down a sixpack or two of stout or hoegaarden ?